Most reasons mentioned below could be coded in ICD-10 codes, it is still certain that many reasons will never be defined in terms of ICD-10 (STI, physicians and patients decision), so to avoid a mixture of two different coding systems it is advised to go with the above list and build upon that for now. This list is identical to the stopping reasons for ART (ART_RS)

Code	Reason for Stopping Treatment
1	Treatment failure (i.e. virological, immunological, and/or clinical failure
1.1	Virological failure
1.2	Partial virological failure
1.3	Immunological failure - CD4 drop
1.4	Clinical progression
10	Hyperlactataemie/lactic acidosis
11	Bone toxicity
15	Social contra-indication
16	Contra-indication unspecified
16.8	Contra-indication expired
16.9	Contra-indication – other
17	MTCT regimen completed
2	Abnormal fat redistribution
3	Concern of cardiovascular disease
3.1	Dyslipidaemia
3.2	Cardiovascular disease
4	Hypersensitivity reaction (skin eruption etc.)
5	Toxicity, predominantly from abdomen/G-I tract
5.1	Toxicity - GI tract
5.2	Toxicity - Liver
5.3	Toxicity - Pancreas
6	Toxicity, predominantly from nervous system
6.1	Toxicity - peripheral neuropathy
6.2	Toxicity - neuropsychiatric
6.3	Toxicity - headache
7	Toxicity, predominantly from kidneys
70	Pregnancy - toxicity concerns (during pregnancy)
75	Pregnancy - switch to a more appropriate regimen for PMTCT
8	Toxicity, predominantly from endocrine system
8.1	Diabetes
88	Death
9	Haematological toxicity (anemia etc.)
90	Side effects - any of the above but unspecified
90.1	Comorbidity
91	Toxicity, not mentioned above
91.1	Toxicity, unspecified
92	Availability of more effective treatment (not specifically failure or side effect related)
92.1	Simplified treatment available
92.2	Treatment too complex
92.3	Drug interaction
92.31	Drug interaction - commencing TB/BCG treatment
92.32	Drug interaction - ended TB/BCG treatment
92.33	Change in eligibility criteria (e.g. child old enough for tablets; refrigerator no longer available)
92.4	Protocol change
92.5	Regular treatment termination (e.g. DAA's for HCV, antibiotics
92.9	Change in treatment not due to side-effects, failure, poor adherence or contra-indication
93	Structured Treatment Interruption (STI)
93.1	Structured Treatment Interruption (STI) - at high CD4
94	Patient's wish/decision, not specified above
94.1	Non-compliance
94.2	Defaulter
95	Physician's decision, not specified above
96	Pregnancy
96.1	Pregnancy intended
96.2	Pregnancy ended
97	Study treatment
97.1	Study treatment commenced
97.2	Study treatment completed
97.6	Drug not available
98	Other causes, not specified above
99	Unknown